Group B Streptococcal b-Hemolysin Induces Mortality and Liver Injury in Experimental Sepsis
نویسندگان
چکیده
Axel Ring, Johann S. Braun, Jürgen Pohl, Victor Nizet, Wolfgang Stremmel, and Jerry L. Shenep Department of Infectious Diseases, St. Jude Children’s Research Hospital, and Department of Pediatrics, University of Tennessee, Memphis; Division of Pediatric Infectious Diseases, University of California, San Diego; Department of Internal Medicine IV, Ruprecht-Karls-University, Heidelberg, and Department of Neurology, Humboldt University, Berlin, Germany
منابع مشابه
Group B streptococcal beta-hemolysin induces mortality and liver injury in experimental sepsis.
New Zealand White rabbits were challenged with the wild-type (wt) group B streptococci (GBS) serotype III strain (COH1) and its isogenic nonhemolytic (NH) and hyperhemolytic (HH) mutants. Mortality differed significantly between rabbits infected with the HH mutant IN40 (67%), compared with rabbits infected with the wt COH1 strain (27%) and the NH strains COH1-20 and COH1:cylEDeltacat (13% and 0...
متن کاملGroup B Streptococcal Sepsis in a Newborn: a Case Report
Newborns’ bacterial infections due to group B Streptococcus (GBS) happen in two forms including early-onset disease or late-onset disease. In this paper, we report a case of early-onset GBS infection in a male infant. A 22-year-old primigravid woman delivers a term normal looking male infant. Nasal flaring, grunting, and poor feeding presented soon after birth. An empiric treatment wit...
متن کاملGroup B streptococcal beta-hemolysin induces nitric oxide production in murine macrophages.
Group B streptococcus (GBS) is the leading cause of sepsis in neonates. Nitric oxide (NO) release plays a role in the hypotension that characterizes septic shock. To examine the role of the GBS beta-hemolysin in NO production, the murine macrophage line RAW 264. 7 was exposed to a wild-type (WT) GBS isolate and to hyperhemolytic (HH) and nonhemolytic (NH) transposon mutants derived from that is...
متن کاملSeverity of group B streptococcal arthritis is correlated with beta-hemolysin expression.
Septic arthritis is a clinical manifestation of group B streptococcal (GBS) infection in neonates and adults. To examine the potential role of GBS beta-hemolysin in joint injury, mice were infected with 2 wild-type strains or with nonhemolytic (NH) or hyperhemolytic (HH) variants derived by transposon mutagenesis. Compared with mice infected with the parent strains, mice infected with the NH mu...
متن کاملComparative evaluation of the therapeutic effects of silymarin and hydrocortisone on clinical and hematological alterations, and organ injury (liver and heart) in low-dose canine lipopolysaccharide-induced sepsis model
The present study aimed to examine the effectiveness of silymarin compared to hydrocortisone on clinical and hematological alterations and organ injury (liver and heart) in a low-dose canine lipopolysaccharide (LPS)-induced sepsis model. Fifteen clinically healthy dogs were randomly categorized into three equal groups: Two dogs in group A, LPS (0.10 μg kg-1, IV) was injected (control...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2002